Tuberculosis (TB) infection is instigated by the bacillus Mycobacterium tuberculosis (MTB). Before COVID‐19, TB was the main cause of infectious disease deaths worldwide. MTB has infected about one‐fourth of the global population. A six‐month medication regimen can effectively treat 85% of those who contract TB. The comorbidity between TB and other infectious diseases is very common in TB‐endemic regions. Human immunodeficiency virus (HIV), malaria, toxoplasmosis, sexually transmitted infections, viral hepatitis, giardiasis, leishmaniasis, and pneumonia are a few examples of infectious diseases that can exist concurrently with TB. The impact of co‐infections and the management of TB patients who are also infected with HIV, malaria, toxoplasmosis, and hepatitis B will be covered in this article.