South Africa has the highest national burden of HIV globally. Understanding drivers of HIV acquisition in recently completed, prospective studies in which HIV was an endpoint may help inform the strategy and investments in national HIV prevention efforts and guide the design of future HIV prevention trials. We assessed HIV incidence and correlates of incidence among women enrolled in ECHO (Evidence for Contraceptive Options and HIV Outcomes), a large, open-label randomized clinical trial that compared three highly effective. reversible methods of contraception and rates of HIV acquisition.

Authors: Thesla Palanee-Phillips, Helen V Rees, Kate B Heller, Khatija Ahmed, Joanne Batting, Ivana Beesham, Renee Heffron, Jessica Justman, Heeran Makkan, Timothy D Mastro, Susan A Morrison, Nelly Mugo, Gonasagrie Nair, James Kiarie, Neena M Philip, Melanie Pleaner, Krishnaveni Reddy, Pearl Selepe, Petrus S Steyn, Caitlin W Scoville, Jenni Smit, Katherine K Thomas, Deborah Donnel, Jared M Baeten, ECHO Trial Consortium.