Journal Club
October 2019: TB APPRISE trial suggests similar maternal safety for IPT initiated during pregnancy or postpartum, but increased risk of adverse pregnancy outcomes
Article and Study Summary Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women. Published in: N Engl J Med 2019; 381:1333-1346. https://www.nejm.org/doi/10.1056/NEJMoa1813060 Authors: Gupta A, Montepiedra G, Aaron L, et al. Summary: The IMPAACT...
September 2019: ADVANCE trial of three ART regimens shows dolutegravir treatments to have noninferior efficacy with standard of care, but cause significantly more weight gain
Article and Study Summary Dolutegravir plus two different prodrugs of tenofovir to treat HIV. Published in: N Engl J Med 2019; 381:803-815. https://www.nejm.org/doi/full/10.1056/NEJMoa1902824 Authors: Venter WDF, Moorhouse M, Sokhela S, et al. Summary: The ADVANCE...
August 2019: SEARCH trial on universal ART intervention shows some benefits, but HIV incidence not lower than with the standard of care
Article and Study Summary HIV testing and treatment with the use of a community health approach in rural Africa. Published in: N Engl J Med 2019; 381:219-229. https://www.nejm.org/doi/full/10.1056/NEJMoa1809866 Authors: Havlir DV, Balzer LB, Charlebois ED, et al....