Primary objective 1: To identify serologic reactivities that differentiate SARS-CoV-2 infection from vaccination. Primary objective 2: To develop and formally qualify a suite of immunologic assays and reference reagents that permit detailed interrogations of the immune response to SARSCoV-2 infection in preparation for similar assessments of vaccine-elicited immune responses and immunotherapeutics. Primary objective 3: To measure SARS-CoV-2-specific adaptive immune responses in order to identify immune markers of COVID-19 disease severity and duration in different demographic groups (eg, age, gender) and in people with different medical histories, including pre-existing conditions, new acute or chronic medical conditions, and concomitant medications. Primary objective 4: To characterize presentations of SARS-CoV-2 infection, including the clinical course of COVID-19, among convalescent individuals.
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HVTN 405/HPTN 1901: Characterizing SARS-CoV-2-specific immunity in convalescent individuals
